Description
Key information
- Function : Clopidogrel works by preventing platelet aggregation (platelets are the blood components involved in forming clots) and the formation of dangerous clots in the arteries, keeping blood flowing smoothly.
- Uses : It is prescribed for patients who have recently had a heart attack or stroke, who suffer from severe chest pain (unstable angina) or from peripheral artery disease. It is also often used in patients who have had coronary angioplasty with stent placement, often in combination with aspirin.
- Dosage : The usual adult dose is one 75 mg tablet once a day, with or without food. In acute coronary syndrome, a higher initial loading dose may be given.
Important warning (boxed warning): Clopidogrel is a prodrug that must be metabolized by the liver enzyme CYP2C19 to become active. Some people have a genetic variation that makes them “poor metabolizers” of this enzyme, which can reduce the medicine’s effectiveness and increase their risk of heart attack or stroke. Doctors can perform a test to detect this genetic difference.
Common side effects : The most common side effect is an increased risk of bleeding, including bruising, nosebleeds and longer bleeding time if you cut yourself. Other side effects may include headache, dizziness, nausea and abdominal pain.
Precautions : Tell your doctor or dentist that you are taking clopidogrel before any surgery or dental procedure, as treatment may need to be stopped temporarily to prevent excessive bleeding. Avoid grapefruit and grapefruit juice, as they can reduce the medicine’s effectiveness.
Always consult your healthcare professional or a qualified pharmacist for personalized medical advice, as this information is only a general overview.
